How Important is Vitamin B12 Deficiency for human body?

Important is Vitamin B12 Deficiency

Vitamin B12, also known as cobalamin, is an essential nutrient that plays an important role in maintaining our health and well-being. Although vitamin B12 is important, many people do not fully understand what it does, why it is important, and how to get it. This blog aims to explain this important nutrient and explore its importance, uses, processes in the body and dietary supplement options available.

Importance of Vitamin B12

Vitamin B12 is a water-soluble vitamin that is essential for various bodily functions. This is very helpful to:

1. Formation of red blood cells: Vitamin B12 is important for the formation of red blood cells, which carry oxygen throughout the body. Without enough vitamin B12, the red blood cells become enlarged and do not function properly, causing megaloblastic anemia.

2. Nervous Function: B12 plays an important role in maintaining the health of the nervous system. It helps in the formation of myelin, the protective layer that surrounds the nerves and helps in the smooth transmission of nerve impulses. Vitamin B12 deficiency can cause neurological symptoms such as numbness, tingling, and in severe cases, cognitive decline.

3. DNA synthesis: B12 is involved in the synthesis of DNA, the genetic material in all cells. This is important for cell division and tissue growth.

4. Mitochondrial Energy Metabolism: As an adjuvant, B12 helps produce energy in cells.

5. Antioxidant properties: B12 has antioxidant properties and helps protect cells from oxidative damage.

6. Epigenetic regulation: B12 participates in epigenetic processes that influence gene expression.

Source of Vitamin B12

The  body cannot produce vitamin B12 on its own so it must be obtained from external sources, such as:

  • Animal products: Foods such as meat (especially liver), fish, eggs, and dairy products are good sources of vitamin B12.
  • Fortified foods: Certain plant foods, such as whole grains, nutritional yeast, and plant-based milks, are fortified with B12.
  • Supplements: Vitamin B12 supplements are widely available and are recommended for those at risk of B12 deficiency, such as vegans, vegetarians, and the elderly.

Mechanism of Action

Vitamin B12 acts in the body as a coenzyme in two important biological reactions:

  1. Methionine synthesis: B12 helps to convert homocysteine ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​with methionine. Methionine is essential for protein synthesis and various biochemical processes.
  • Methylmalonyl coenzyme A mutase: The conversion of methyl malonyl coenzyme A to succinyl coenzyme A also requires B12.

These processes are critical for energy production, DNA synthesis, and myelin maintenance, which explains why B12 levels are so important for overall health.

Indications for B12 therapy:

B12 supplementation may be necessary for many reasons, including:

  • Deficiency: Blood tests show low levels of vitamin B12.
  • Neurological disorders: B12 therapy has been shown to be effective in multiple sclerosis, Parkinson’s disease, and myalgic encephalomyelitis.
  • Other conditions: Some research suggests a role for B12 in autism and amyotrophic lateral sclerosis (ALS).

Nutraceutical containing vitamin B12

Nutraceuticals are food products that provide additional health benefits in addition to the direct nutritional value of food. For vitamin B12, several dietary supplements are available:

1. Sublingual B12 Tablets: These tablets dissolve under the tongue and are quickly absorbed into the bloodstream, avoiding the problems of absorption in the stomach.

2. B12-fortified foods: Many fortified foods, such as butter, fortified breadcrumbs, and nutritional yeast, are great for vegans and vegetarians.

3. B12 injections: If you have severe deficiency or malabsorption issues, your health care provider may recommend B12 injections to improve absorption.

Abha’s Vitamin B12 – Abha Biotechnology Pvt. Ltd., a top third-party nutraceutical manufacture, is known for producing many top level supplements which includes Vitamin B12 supplement. Here are more details: –


60, 90, 120 capsules

Ingredients: – Vitamin B12 (Cyanocobalamin) with Herbal Powders


  • Helps to Manage Anemia.
  • Beneficial for Healthy Nervous System & Cardio Vascular Health


In short, vitamin B12 is an essential nutrient that plays an important role in red blood cell formation, nerve function, and DNA synthesis. Deficiency can lead to serious health problems, so getting the right amount from food and supplements is important. Knowing the importance of vitamin B12 and its various sources allows people to make choices that support their health and well-being. 

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